1988 Volume 79 Issue 9 Pages 1504-1509
To evaluate glomerular dysfunction of refluxing kidney, microalbuminuria was assessed using RIA in 84 children with primary VUR.
Albumin excretion increased in 40% of children with VUR. A remarkable increase of albumin excretion was recognized in children over 5 years old, which suggests that glomerular dysfunction of refluxing kidney progresses with aging.
Although the cases with high grade VUR and with renal cortical scar or unilateral severely impaired renal function on DMSA renoscintigraphy showed a tendency of high albumin excretion, neither grade of VUR nor severity of renal dysfunction correlates well with the degree of microalbuminuria. Even in three cases out of five that revealed high level of serum α1-microglobulin, albumin excretion was either normal or elevated only slightly.
