The Japanese Journal of Urology
Online ISSN : 1884-7110
Print ISSN : 0021-5287
ISSN-L : 0021-5287
STAGE IV RENAL CELL CARCINOMA PRODUCING α-FETOPROTEIN TREATED WITH MULTIMODAL TREATMENT A Case Report
Kazuhiro TakaiTadao KakizoeKen-ichi TobisuYoshinori TanakaTomoyuki GoyaTaizou KondoYuichi KajiuraSunao EgawaShin-ichi TeshimaKiyozo KishiTeruaki Sekine
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1989 Volume 80 Issue 1 Pages 104-110

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Abstract

A 63 year old man, having right renal cell carcinoma which was found after initial symptoms of left supraclavicular tumor and gross hematuria, is presented. The points to note with this case are; (1) An unusual production of alpha-fetoprotein (AFP), (2) Being discovered at a very advanced stage and that the disease progressed rapidly (at initial presentation the patient had lymph nodes metastases from the paraaorta, mediastinum to the left supraclavicular region. Later the patient had a recurrent tumor in the left supraclavicular area and multiple cutaneous metastases), (3) Various modalities of treatment were given (right nephrectomy, abdominal lymph nodes dissection, resection of the supraclavicular and mediastinal lymph nodes metastases, hyperthermia combined with irradiation for the recurrent tumor in the supraclavicular region and systemically adoptive immunotherapy with tumor infiltrating lymphocytes). During this treatment course, the drift of serum AFP showed a good correlation.
The possiblity of AFP as a tumor marker of renal cell carcinoma in selected cases was presented and the suitablity of the treatments performed to this patient was discussed.

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