The Japanese Journal of Urology
Online ISSN : 1884-7110
Print ISSN : 0021-5287
ISSN-L : 0021-5287
CLINICAL EVALUATION OF SERUM BASIC FETOPROTEIN
Comparative Study with Serum Immunosuppressive Acid Protein
Kazuo GohjiSoichi ArakawaOsamu MatsumotoSadao KamidonoHideo OshimaHitoshi NagataTakahiro IwamotoKuhei HirookaNoboru ShimataniTakaaki InoueHirokazu TanakaNozomu YamanakaToshio ImaiOsamu TomiokaAkira FujiiMasayuki KuwayamaNoboru ItoYasushi NakagawaHideki UeharaKenji Harada[in Japanese][in Japanese][in Japanese]Hiroshi YamazakiKenji MinayoshiYoshi-hiko KitanoKei-ichi UmezuMasuo YamashitaAtsushi SengokuHiroshi SaitoKoichi UenoAtsushi ItaniShigenori MiyazakiTakayoshi OgawaTakao SakumaNobuo KataokaYoko InabaMasami MatsushitaShuso DenToru ObeMitsushi YoshimuraTakehiro IzumiJiro Miyazaki[in Japanese][in Japanese][in Japanese]Masaru Ishii
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1989 Volume 80 Issue 5 Pages 711-718

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Abstract
The clinical significance of serum basic fetoprotein (BFP) in renal cell carcinoma was investigated in comparison with serum immunosuppressive acid protein (IAP). Investigated in this study were 46 patients with renal cell carcinoma, 31 males and 15 females ranging in age from 40 to 85 years (mean age: 56 years). According to Robson's system of staging, 10 cases (22%) had a stage I disease, 14 cases (30%) a stage II disease, and 18 (39%) a stage IV disease. The positivity rate for and levels of serum BFP were found higher as disease stage avanced, with 54% of the entire cases and 72% of stage IV cases being positive for serum BFP. On the other hand, 76% of 34 cases for whom assay of serum IAP was feasible and 79% of stage IV cases were positive for serum IAP, thus here again the positivity rate for and serum levels of the marker became increasingly higher with avancing disease stage. Simultaneous assay of serum BFP and IAP demonstrated that 85% of stage IV renal cell carcinoma cases were positive for at least one of the two marders. A study of changes in these tumor markers before and after curative resection of the tumor showed that BFP decreased below the preoperative level within 1 week postoperatively in 92% and even returned to nomal in 75% of cases who were positive for the tumor markers preoperatively, while serum IAP reduced below the preoperative level in 82% and returned to nomal in 27% of the cases preoperatively.
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© Japanese Urological Association
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