1990 Volume 81 Issue 10 Pages 1473-1479
Six patients, with advanced germ cell tumor refractory to prior chemotherapy including cis-platinum and etoposide, were treated by high dose chemotherapy and autologous bone marrow transplantation. Etoposide (1200-1800mg/m2), cyclophosphamide (120mg/kg) and cis-platinum (60-120mg/m2) were given and the autologous bone marrow was infused 72 hours after the last dose of chemotherapy. Two patients were treated by high dose chemotherapy three times. The regimen of the third high dose chemotherapy was etoposide (1800mg/m2), cyclophosphamide (120mg/kg), adriamycin (80mg/m2), ACNU (200mg/m2) and 254S (100mg/m2). One patient died of cerebral hemorrhage 7 days after ABMT. Of the 5 patients evaluable for response, 4 responded: one patient obtained a complete response and 3 a partial response.
