IMMUNOHISTOCHEMICAL STUDIES ON BLADDER TUMOURS

Evaluation by CEA, Ferritin, β₂-MG, Keratin and Glycogen

Abstract

The focus of my study was the immunohistological expressions of bladder tumour cells when stained by several antigens, those being; Carcinoembryonic antigen (CEA), Ferritin, Beta 2 Microglobulin (β2-MG), Keratin and Glycogen. There were 59 cases of bladder cancer studied using the Peroxidase-antiperoxidase technique (PAP) of staining. Specimens were formalin-fixed, parrafin embedded, and then sectioned.
Some correlation was found between histological grade, stage and CEA incidence but was not found in the Ferritin or β2-MG. Keratin and Glycogen were detected in all cases. These staining patterns were mosaic according to higher grade and stage. It is believed this demonstrates that immunohistochemical expressions of staining with CEA, Keratin, and Glycogen may be a sensitive indicator of histological grade, stage.