1993 Volume 84 Issue 3 Pages 541-545
Thirty-one patients (26 male and 5 female patients) of non-hypercalciuric Ca stone formers were studied concerning their bone metabolism. We measured plasma free γ-carboxyglutamic acid, plasma hydroxyproline, urinary free γ-carboxyglutamic acid and urinary hydroxyproline as markers of bone metabolism.
Plasma free γ-carboxyglutamic acid level showed significantly higher in stone formers than normal controls (1.01±0.37nmol/ml vs 0.39±0.13nmol/ml). But no significant difference were observed in plasma hydroxyproline level (1.99±0.73μg/ml vs 2.27±0.92μg/ml), urinary free γ-carboxyglutamic acid (52.0±17.6nmol/mg·Cr vs 45.7±9.8nmol/mg·Cr), and urinary hydroxyproline (3.87±2.02μg/mg·Cr vs 3.33±1.63μg/mg·Cr).
In conclusion, these results suggest that abnormality of bone metabolism may be not a primary event in causing stone formation in these patients.
