The Japanese Journal of Urology
Online ISSN : 1884-7110
Print ISSN : 0021-5287
ISSN-L : 0021-5287
THE ANALYSIS OF THYMIDINE PHOSPHORYLASE EXAMINED BY ELISA IN BLADDER CANCER
Michihisa SaegusaAkira TakaoDaisuke ManabeTakaharu IchikawaKenji AramakiYasuki NakayamaDaisuke Yamada
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2002 Volume 93 Issue 7 Pages 743-749

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Abstract

(Purpose) Some reports suggest that the high level expression of thymidine phosphorylase (TP), which is known as one of angiogenic factors, is related to high malignancy and also poor prognosis in the field of gastrointestinal cancer. So the authors investigated the expression of TP in bladder cancer.
(Materials and methods) The expression of TP in cancer tissues and normal tissues, which were obtained during transurethral resection of the tumor of 66 patients with initial primary bladder cancer, was examined by enzyme-linked immunosorbent assay (ELISA). And relationship of the TP expression and clinicopathologic factors was investigated.
(Results) The level of TP expression was significantly high in cancer tissues compared with normal tissues (P<0.0001). About the level of TP expression of cancer tissues, there was a significant difference between G1 and G3 in grade (P=0.0099), Ta and T2 or greater (P=0.0059), Ta, T1 and T2 or greater (P=0.0157) in T stage, papillary and non-papillary in surface form (P=0.0056), pedunculated and sessile in tumor shape (P=0.0458), and 1cm or under and 3cm or greater in size (P=0.0267). The level was higher in latter, respectively. About the level of TP expression of normal tissues, the level was significantly higher in the cases with sessile tumor than the cases with pedunculated tumor (P=0.0078).
(Conclusion) There is correlation between the level of TP expression of cancer tissues and their grade of malignancy, so we can expect that the level of TP expression of cancer tissues will be a prognostic factor. And what does it mean in the fact that the level of TP expression of normal tissues in patients with sessile tumor is higher? It should be clear after accumulation of the cases and collecting the episodes in the follow-up period.

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