2025 Volume 36 Issue 1 Pages 75-81
It is well established that adipose-derived stem cells ( ADSCs ) , a type of mesenchymal cell present in adipose tissue, possess regenerative effects on peripheral nerves. Consequently, stromal vascular fraction ( SVF ) cells, which is obtained by enzymatically digesting adipose tissue collagen using collagenase, has been explored for clinical applications.
More recently, a novel method has been reported in which micronized cellular adipose matrix ( MCAM ) is extracted through physical processing of adipose tissue, allowing for the efficient and rapid concentration of stromal cells and extracellular matrix components. Since MCAM production does not require collagenase treatment, it is subject to fewer regulatory constraints than SVF cells and can be used more safely and in a shorter timeframe.
Given these advantages, MCAM holds promise as a novel therapeutic product for promoting peripheral nerve regeneration. This review provides an overview of the regenerative effects of MCAM on peripheral nerves and discusses its clinical applicability and future prospects in comparison with SVF cells.
