2025 Volume 10 Issue 1 Pages 1-9
The skin, as the outermost barrier, harbors a unique microbial consortium. While the skin microbiota plays a crucial role in maintaining homeostasis, disruptions in host-microbe interactions have been associated with chronic inflammatory skin conditions such as atopic dermatitis and psoriasis vulgaris. However, the specifics of individual host-microbe interactions, particularly their anti-inflammatory effects that would serve as seeds for therapeutic agents, remain largely unexplored. Furthermore, how the skin environment that is colonized by microbiota affects the bacterial metabolic activity is undetermined. In this article, we introduce that Staphylococcus cohnii can suppress skin inflammation via promotion of glucocorticoid synthesis in the skin and the proteomic approach used for gene expression analysis of bacteria colonized on the skin. Additionally, we will present the latest findings on the stratum corneum, the outermost layer of the skin, where skin microbiota colonize. By using various methods including proteomic analysis, we expect to elucidate beneficial host-microbe interactions and develop new treatments using skin microbiota.
