Overview and Perspective of Proteomics in the Sight of a Researcher Committed to Proteomics of the Glomerulus of Kidney

Abstract

I started my research on proteomics of the glomerulus of kidney almost 15 years ago when proteomics was at its initial stage and in a frenzy of anticipation. Through the research I have experienced a lot of frustration as well as pleasures in working with mass spectrometers. In this short review, I would like to summarize history and achievements of our research. This review, however, start with overview and perspective of proteomics field in the sight of a researcher deeply committed to proteomics for long years. It includes ambiguity of protein identification, tremendous heterogeneity of proteome, brief history of proteomics and current challenge confronting proteomics. I then briefly summarize our research including recent works. Finally I would like to depict my personal view on prospects of proteomics.