Abstract
Serum enzyme and electrolyte changes associated with Gambian trypanosomosis (sleeping sickness) were studied in vervet monkeys infected with Trypanosoma brucei gambiense.
Although Serum aspartate aminotransferase (ASAT) and alanine aminotransferase (ALAT) concentrations of the monkeys increased at various points after infection, the levels of alkaline phosphates (AP) decreased. Similarly, serum sodium and potassium levels increased while those of calcium and phosphate decreased. These changes suggested that hepatic, renal and parathyroid damage are some of the pathological features of Gambian sleeping sickness in man leading to early death of untreated persons.
