Hepatic Oxidative Stress and Antioxidant Defenses During Chloroquine-Resistant and Sensitive Plasmodium berghei Infection in Mice

Abstract

Comparative study on hepatic oxidative stress and antioxidant defense systems of mice infected with chloroquine-resistant (CQ-R) or chloroquine-sensitive (CQ-S) Plasmodium berghei K173 strain revealed that P. berghei CQ-S strain infection makes the mice more vulnerable to oxidative damage as compared to P. berghei. CQ-R strain infection. The levels of superoxide, lipid peroxidation, glutathione and xanthine-oxidase were significantly increased while, superoxide-dismutase and catalase showed a marked decrease during CQ-S P. berghei infection when compared to CQ-R P, berghei- infected host.