Abstract
Hepatic microsomal mixed function oxidase system was significantly inhibited/impaired during chloroquine-resistant and chloroquine-sensitive Plasmodium berghei K-173 strain infection in mice compared to normal. Cytochrome P-450, cytochrome b5, aniline-hydroxylase, aminopyrine-N-demethylase and benzo(a)pyrene-hydroxylase were more affected due to chloroquine-sensitive as compared to chloroquine-resistant P. berghei infection in mice. Hepatic microsomal heme levels were increased during P. berghei infection as compared to normal but the increase was more in chloroquine-sensitive as compared to chloroquine-resistant P. berghei infection in mice.
