Efficacy of Trypanocidal Drugs on Experimentally Induced Trypanosomiasis in Racing Camels

Abstract

A study was conducted to assess the efficacy of three trypanocidal drugs, viz. melarosamine, diminazine and quinapyramine, in the treatment of experimental Trypanosoma evansi infection. Sixteen camels were divided into four groups (four camels per group). Groups Ⅰ, Ⅱ and Ⅲ were treated with melarosamine, diminazine and quinapyramine, respectively. Group Ⅳ served as non-infected and non-treated control. Within each groupⅠ, Ⅱand Ⅲ, one camel was kept as infected non-treated control. Cure rates of 66.66％, 66.66％ and 33.33％ were recorded, for melarosamine, diminazine and quinapyramine treated camels, respectively. Some hematological and blood biochemistry parameters were also recorded on control and trypanosome infected camels. The mean Packed Cell Volume (PCV) of infected animals dropped from 29±3 to 21.35±6.5 before treatment. The mean value of neutrophils, eosinophils, basophils，lymphocytes and monocytes were 32.7％, 1.80％, l.06％, 62.4％ and 1.30％, respectively. Value of mean total protein was 8.92g/dl while Albumin and Globulin were 2.62g/dl and 6.20g/dl respectively.