Proceedings for Annual Meeting of The Japanese Pharmacological Society
Online ISSN : 2435-4953
The 92nd Annual Meeting of the Japanese Pharmacological Society
Session ID : 92_1-S08-2
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Host: The 92nd Annual Meeting of the Japanese Pharmacological Society

Name : The 92nd Annual Meeting of the Japanese Pharmacological Society

Number : 92

Location : Osaka

Date : March 14, 2019 - March 16, 2019

Symposium
New three molecule regulate the dependece by methanphetamine
*Atsumi Nitta
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CONFERENCE PROCEEDINGS OPEN ACCESS

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Abstract

We found and study new three molecules related methamphetamine dependence, Shati/Nat8L, Piccolo and TMEM168. Accumbal Shati rescue the dependence-induced by methamphetamine via mGluR3, and dopaminergic deficiency. Reduce of Piccolo can inhibit methamphetamine dependence via GABA regulation. TMEM168 also inhibit the methamphetamine dependence via osteopontin pathways. We found some pathway to establish drug dependence. We expected them for the new medical target for the drug dependence.

Recently, we attempt to find these molecular regulation system to develop new medical tool. Here we would like to recent our results

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