Platform type of drug repositioning/rescue by mimicking cell-state change

Abstract

We developed a platform for drug repositioning/rescue by using omics data that express the cell-state changes by drug administration, based on the concept of well-known "connectivity map", which the transcriptome data by drug administration is connected to drug efficacy. In addition to connectivity-map approach, the platform is equipped with an original method to estimate the drug efficacy based on the network analyses. Furthermore, the platform is also equipped with a workflow to estimate new stratification markers of the indications newly found by drug repositioning. Note that in principle, the platform type of drug repositioning/rescue can provide solutions of commercialized drugs against any kind of target diseases. We will illustrate our platform performance with some practical applications, especially in terms of the increase of certainty of new findings, at the spot.