Host: The 92nd Annual Meeting of the Japanese Pharmacological Society
Name : The 92nd Annual Meeting of the Japanese Pharmacological Society
Number : 92
Location : Osaka
Date : March 14, 2019 - March 16, 2019
Since the identification of endogenous H2S in the mammalian brain in 1989, studies of this molecule uncovered physiological roles in processes such as neuromodulation, vascular tone regulation, cytoprotection against oxidative stress. We previously demonstrated that H2S induces Ca2+ influx in astrocytes by activating transient receptor potential (TRP) channels. During this study we found that H2Sn activates TRP ankyrine 1 (TRPA1) channels much more potently than does H2S and that 3-mercaptopyruvate sulfurtransferase (3MST) produces H2S2 and H2S3. Recently, we demonstrated that the chemical interaction of H2S with nitric oxide (NO) generates H2S2 and H2S3 that may be a mechanism of a synergistic effect between H2S and NO we previously showed in the regulation of vascular tone. We showed that cysteine persulfide (Cys-SSH) together with its glutathione (GSH) counterpart (GSSH), both of which have been proposed to be involved in redox homeostasis, are also produced by 3MST. We will show our recent observation that sulfite protects neurons from oxidative stress more efficiently than H2S and H2Sn with a distinctive mechanism.
