Host: The Japanese Pharmacological Society
Name : The 96th Annual Meeting of the Japanese Pharmacological Society
Number : 96
Location : [in Japanese]
Date : November 30, 2022 - December 03, 2022
Acute kidney injury (AKI) is a catastrophic disease with high morbidity and mortality in hospitalized patients and contributes to the pathogenesis of chronic kidney disease. However, there are no approved effective treatment for AKI. There are many causes of AKI, including ischemia, hypoxia, and nephrotoxicity. The primary cause is ischemia reperfusion injury, due to trauma, shock, sepsis, and renal transplantation. Previous studies have shown radical scavenging activity and anti-inflammatory activity of an alkali extract of Sasa sp. The present study aimed to evaluate the efficacy of an alkali extract of Sasa sp. in AKI model mice. AKI was induced by temporary vascular clamping of the left kidney for 45 min followed by reperfusion, two weeks after removal of right kidney. We have measured the renal function using urine and serum, and morphological assessment. The levels of inflammation markers in the kidney have also been measured by ELISA. An alkali extract of Sasa sp. improved the renal function, the damage of renal tubules and exhibited anti-inflammatory in the kidney. These findings indicate that an alkali extract of Sasa sp. protects kidney in AKI model mice.
