The use of fresh human blood in drug discoveryresearch

Abstract

In the research and development of pharmaceuticals, the efficacy and safety areevaluated in non-clinical trials using animals or commercialized human frozencells before actually administering them to humans in clinical trials. However,compared to the use of fresh human blood or cells, it often does not reflect invivo functions, and extrapolation to humans is not necessarily high. In otherwords, by using fresh human blood, it is possible to accurately evaluate thedrug response in cell function, and pharmacodynamic (PD) assay can lead totranslational research to clinical trials.

In this presentation, I will explain the use of fresh blood by showingexamples.