Abstract
The acute toxicity testing is conducted as a part of chemical hazard identification. The endpoint of acute toxicity is death, which is the ultimate toxicity and the lethal dose 50% (LD50) have been used because of the convenience of showing the toxicity intensity of compounds as a common index. On the other side, death is not a desirable endpoint from the viewpoint of animal welfare. Moreover, the significant shortcoming of acute toxicity study is that it is not useful for the medical treatment of human poisoning because the cause of death, target organs, etc. are not considered at all. In order to solve these issues concerning acute toxicity study, it is great way to obtain valid result with precisely measure and quantify the signs of toxicity over multiple items, and make rational criteria for determining the severity of their toxicity. This will be, however, a complicated and expensive test than a study with a mortality endpoint. For modernization of acute toxicity, we are focusing on multiple vital signs. As a part of this project, we have established a less invasive method of measuring biopotential by carbon nanotube yarn. In this presentation, we would like to new approach for assessment of acute toxicity by multiple parameters of vital signs. (Health and Labour Sciences Research Grant, Japan)
