Host: The Japanese Pharmacological Society
Name : The 96th Annual Meeting of the Japanese Pharmacological Society
Number : 96
Location : [in Japanese]
Date : November 30, 2022 - December 03, 2022
Aging is the gradual but progressive decline of physiological function in cellular and tissue levels, eventually leading to the disruption of homeostasis in an individual organism. Advancing age is known to be one of the risk factors for various diseases and mortality, but the quantification and intervention are challenging. Aging hallmarks are well characterized while they are not exclusively specific to aging, and dependent on context, cell type and disease state. In addition, aging process is used to be considered as unidirectional. However, the generation of iPS cells demonstrates that terminally differentiated somatic cells can be reverted to embryonic like state while keeping genetic information. Owing to going through the iPS cell state, we can obtain rejuvenated phenotype of cells and tissues. Intriguingly, vigorous research for understanding the iPS cell reprogramming process has also demonstrated that the partial reprogramming reverses many age-associated changes without going through iPS cell state. In this presentation, I will introduce and discuss the potential of partial reprogramming against age-associated changes and the process which gives insight for the mechanisms.
