Abstract
In pharmacology textbooks, explanations are provided about the physiological activities of primarily five prostaglandins and thromboxane that are mainly produced through the activity of cyclooxygenase from the unsaturated fatty acid arachidonic acid, as well as the pharmacological actions of SAIDs and NSAIDs that inhibit their metabolism. With the advancement of omics technologies, it has become evident that not only these major lipid metabolites but also many other lipid metabolites dependent on various substrates and enzymes are produced and metabolized within the body. When comprehensively evaluating lipids produced and excreted in tissues and body fluids of diseased tissues or fluids, specific lipid production profiles reflecting each pathology are observed. These technologies can be applied as biomarkers and can also be used in the exploration of novel bioactive lipids. In our laboratory, we have utilized comprehensive concentration measurement techniques for bioactive lipids (lipidomics) to evaluate lipid profiles in tissues and body fluids of patients and animal models with allergic diseases such as food allergies, atopic dermatitis, and allergic rhinitis. Additionally, we have conducted explorations of the bioactivity of lipid metabolites produced therein. As a result, we have made discoveries related to biomarkers for food allergies and atopic dermatitis excreted in urine, as well as multiple lipids that exacerbate allergic inflammation. In this presentation, we would like to report these research findings.
