Immune profiling for understanding vaccine immunogenicity and reactogenicity

Abstract

COVID-19 pandemic underscored the critical need for swift deployment of essential medical countermeasures, with vaccines playing a pivotal role. The successful development of vaccines hinges on the availability of a high-throughput platform that facilitates the rapid assessment of vaccine immunogenicity and reactogenicity. Given that these vaccine properties commonly originate from vaccine-elicited immune responses, it is imperative to gain a comprehensive understanding of vaccine immunity from multiple perspectives and at sufficient depths. In response to the challenges posed by the COVID-19 pandemic, cutting-edge technologies have been introduced to profile the immune system at both molecular and cellular levels. These advancements provide crucial insights into the dynamics of the immune system and identify molecular/cellular targets for innovative evaluation systems. This presentation highlights the potential of immune profiling, showing examples from COVID-19 and other vaccines to illustrate the impact and possibilities of these advancements.