Host: The Japanese Pharmacological Society
Name : The 97th Annual Meeting of the Japanese Pharmacological Society
Number : 97
Location : [in Japanese]
Date : December 14, 2023 - December 16, 2023
In the early 1990s, the amyloid cascade hypothesis was proposed based on genetic research into familial Alzheimer's disease (AD) as the mechanism of AD onset and progression. Subsequently, numerous clinical trials of agents based on this hypothesis were conducted, leading to many failures. However, these research results contributed to 1) the identification of toxic species, 2) the selection of the appropriate subject population, 3) the logical determination of dosages and administration durations based on biomarkers, and 4) the development of highly sensitive primary endpoints. This presentation provides an overview of the history of anti-Aβ drug development, non-clinical research on mechanisms of action, and clinical trial results, including biomarkers. It also outlines the prospects for future Alzheimer's disease drug development.
