Peripheral neuro toxicity assessment by neurite morphological analysis using an microfluidic microphysiological systems

Abstract

Chemotherapy induced peripheral neuropathy is a major common adverse event associated with neurological abnormalities. Due to the multifactorial mechanisms of toxicity, there is an issue with the low predictive accuracy of toxicity observed.In this presentation, we introduce a method for predicting peripheral neuropathies and mechanism of action using the microfluidic device combined with morphological analysis.