Host: The Japanese Pharmacological Society
Name : The 97th Annual Meeting of the Japanese Pharmacological Society
Number : 97
Location : [in Japanese]
Date : December 14, 2023 - December 16, 2023
The alarming global increase of neuron-related diseases such as neurodegeneration and obesity suggest an urgent need for new therapeutic strategies. Current anti-obesity drugs are limited by off-target actions, and further research is needed to identify new targets and effective therapeutic approaches to regulate metabolism. Targeting brain lipid metabolism is a promising strategy to regulate energy balance and fight metabolic diseases tightly controlled by brain cells. The development of stable platforms for selective delivery of drugs, particularly to the hypothalamus, is a challenge but a possible solution for these diseases. Attenuating fatty acid oxidation in the hypothalamus via carnitine palmitoyltransferase 1A (CPT1A) inhibition leads to satiety, but this target is difficult to reach in vivo with the current drugs. We propose using an advanced crosslinked polymeric micelle-type nanomedicine that can stably load a CPT1A inhibitor for in vivo control of energy balance, leading to a rapid attenuation of food intake and body weight in mice via regulation of appetite-related neuropeptides and neuronal activation driving changes in the liver and adipose tissue. This investigation might contribute to the development and validation of a new generation of nanomedicine-based approaches targeting brain cells.
