Host: The Japanese Pharmacological Society, The Japanese Society of Clinical Pharmacology
Name : WCP2018 (18th World Congress of Basic and Clinical Pharmacology)
Location : Kyoto
Date : July 01, 2018 - July 06, 2018
The basic tenet of electrolyte balance has been that extracellular bodily fluids readily equilibrate, allowing the kidney to achieve strict constancy in body Na+ content. Led by discrepancies in human Na+ balance studies, we encountered findings causing us to question the assumption that electrolyte concentration in the interstitium does not substantially deviate from plasma.
In the skin, Na+ storage is not only a component of immunological host defense across the species, but also closely coupled with systemic blood pressure regulation by homeostatic immune cells. In humans, skin Na+ storage occurs with essential hypertension and left ventricular hypertrophy, suggesting that skin osmolyte metabolism contributes to cardiovascular risk.
Body water conservation is another biological pattern of salt excretion. This requires energy-intense urea production by liver and skeletal muscle, which couples increased salt consumption with increased food intake, reprioritization of energy metabolism in liver and skeletal muscle, and a hormone profile which predisposes to muscle loss, fat accumulation, insulin resistance, and diabetes mellitus.
