Proceedings for Annual Meeting of The Japanese Pharmacological Society
Online ISSN : 2435-4953
WCP2018 (The 18th World Congress of Basic and Clinical Pharmacology)
Session ID : WCP2018_OR11-3
Conference information

Oral session
Analyses of Adverse Drug Reactions Nationwide Active Surveillance Network: Canadian Pharmacogenomics Network for Drug Safety (CPNDS) database
Reo TanoshimaAmna KhanAgnieszka K BialaJessica N TruemanBritt I DrogemollerGalen Eb WrightGabriella Ss GroenewegColin Jd RossBruce C Carleton
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CONFERENCE PROCEEDINGS OPEN ACCESS

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Abstract

Background

Adverse drug reactions (ADRs) are a major problem in modern medicine, representing the 4th highest cause of mortality in Western society. Pharmacogenomic tests are one of the most effective and promising methods to solve the problems related to ADRs. The pan-Canadian active surveillance network, Canadian Pharmacogenomics Network for Drug Safety (CPNDS), has successfully identified predictive genomic biomarkers of ADRs, especially in the pediatric oncology field. CPNDS is composed of 26 sites across Canada, and clinical information of ADRs is entered into our host database. Patients' biological samples are also collected for genetic analyses.

Objectives

The objective of this study is to describe an overview of the drugs, ADRs, and clinical information housed in the current CPNDS database.

Methods

The clinical information entered into the database between May 15, 2005 and May 9, 2017 was collected and analyzed using Excel® (Microsoft) and SPSS® (IBM). This included demographic information, number of ADR reports, reports of drug use without ADRs (matched controls), date of ADR occurance, suspected drugs, and fatal cases. The reactions were categorized into 38 common and/or clinically important reaction categories.

Results

The CPNDS database consisted of 93,974 reports of medication use. It comprised of 10,475 ADR reports, of which 72.6% occurred in pediatric patients (≤ 21 y/o) and 27.4% were experienced by adults (> 21 y/o), and 83,499 matched controls. The self-reported ancestry of captured patients were largely from Europe (38.15%), Canada (9.63%) and East Asia (4.86%). The five most frequent ADRs were skin rash (12.25%), peripheral neuropathy (11.57%), cardiotoxicity (7.16%), central nervous system toxicity (6.38%), ototoxicity (5.36%) and the five most common suspected drugs were methotrexate (9.66%), vincristine (7.64%), doxorubicin (6.84%), cisplatin (5.00%), and L-asparaginase (4.64%). Highly significant and clinically relevant biomarkers of ADRs including anthracycline-induced cardiotoxicity and cisplatin-induced hearing loss have been discovered and replicated using the CPNDS database thus far.

Conclusions

Potent pharmacological agents such as cancer chemotherapy used at high-dose to prolong life are dominant ADRs in the database. The CPNDS database is a valuable global resource to identify clinical and genomic predictors of ADRs.

(This work was done by CPNDS consortium.)

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