Host: The Japanese Pharmacological Society, The Japanese Society of Clinical Pharmacology
Name : WCP2018 (18th World Congress of Basic and Clinical Pharmacology)
Location : Kyoto
Date : July 01, 2018 - July 06, 2018
Heme oxygenase (HO) is an important enzyme in heme metabolism that produces biliverdin, carbon monoxide and iron, supply for malaria parasite growth. The polymorphisms in promoter region of heme oxygenase-1 (HO-1) gene in individual may affect to the malaria severity. The objective of this study was to investigate the allele and genotype frequencies of (GT)n repeats polymorphisms of HO-1 promoter in malaria patients in Thailand. Blood samples were collected from two hundred malaria patients from Kanchanaburi (Thai-Myanmar border) and Yala province (Thai-Malaysian border) for analysis of HO-1 promoter polymorphisms by polymerase chain reaction (PCR). The (GT)n repeat alleles were categorized to short (S) (less than 27 repeat) and long (L) (more than or equal to 27 repeat). According to the result, three genotypes were classified as S/S (9.5%), S/L (14%) and L/L (76.5%). Samples collected from two endemic regions showed different genotype frequency, higher frequency of S/S genotype was found in Yala while higher frequency of L/L was found in Kanchanaburi region. Significantly higher frequency of S/S genotype was found in Yala compared to Kanchanaburi region (p = 0.008). Polymorphism of HO-1 promoter in these two endemic areas may contribute to different malaria severity.
