Abstract
Background: The basis of the treatment of schizophrenic patients is using antipsychotic drugs, especially atypical antipsychotic drugs. Given the amount of evidence suggesting an association between atypical antipsychotic drugs and cardiovascular disease, obesity, type 2 diabetes, hypertension, and dyslipidemia. Studies regarding the association between increased blood glucose concentration with the administration of atypical antipsychotic medicine in the schizophrenic patient in Indonesia is still limited.
Objective: The aim of this study was to determine association between atypical antipsychotic medicine with elevated blood glucose levels in schizophrenic patients
Methods: This study utilized observational analytical method using cross-sectional approach. The samples of this study were all hospitalized schizophrenia patients in RSJ Grhasia who had consumed atypical antipsychotic medicine either as monotherapy or multi-drug therapy for 6 - 9 months in 2015 - 2017. The secondary data was obtained from the medical records of patients with schizophrenia. The data that would be retrieved include age, weight, height, gender, types and a therapeutic dosage of the drugs, and Random Blood Glucose (RBG) concentration.
Results: Atypical antipsychotic drugs have a pure association with elevated blood glucose levels in schizophrenic patients. This is indicated by the results of the Multivariate analysis in the form of RBG = 0.752 + 0.293 * Atypical equation.
Conclusion: There is an association between the use of atypical antipsychotic medicine against elevated levels of RBG. Based on the equation it is found that atypical drugs can cause RBG changes of 0.293.
