Host: The Japanese Pharmacological Society, The Japanese Society of Clinical Pharmacology
Name : WCP2018 (18th World Congress of Basic and Clinical Pharmacology)
Location : Kyoto
Date : July 01, 2018 - July 06, 2018
Sleep is an essential and fundamental physiological process that plays crucial roles in the balance of psychological and physical health. Sleep disorder may lead to adverse health outcomes. The effects of sleep deprivation were extensively studied, but its mechanism is still not fully understood. In this study, a label-free quantitative proteomics technology was used to survey the global changes of serum proteins abundance between normal rats and sleep deprivation rats. A total of 446 proteins were detected in the serum samples and among them, 218 proteins showed more than 1.5-folds abundance alterations between the two groups. This study highlights the significant alterations of serum proteins abundance between normal rats and sleep deprivation rats. Functional enrichment and network analyses of the differential proteins revealed a close relationship between sleep deprivation and several biological processes including energy metabolism, cardiovascular function and nervous function. Four proteins including pyruvate kinase M1, clusterin, kininogen1 and profilin-1were identified and validated as potential biomarkers for sleep disorders. This study provides further insight into the pathological and molecular mechanisms underlying sleep disorders at protein level.
