Abstract
Background. Previous study showed that ethyl acetate of Lawsonia inermis Linn. leaf extract (EAE), 1 g/kg, have antihyperglycemic activity in streptozotocin-induced diabetic rats (SDR).
Aim.The present study was conducted to evaluate the effect of three different doses of EAE on blood glucose level, superoxide dismutase (SOD) level and hepar.
Methods. EAE was obtained by serial extraction using n-hexane and ethyl acetate (EAE). EAE than were given to SDR for 14 days daily at three doses (1000, 500, and 250 mg/kg b.w.). Blood glucose level (BGL), SOD level and a histological study of the liver were evaluated.
Results: As compared to diabetic control (DC), Three doses of EAE caused significant reduction (p < 0.01-p<0.001) of BGL. Only EAE 1g/kg b.w increased SOD level significantly (p<0.01). EAE-treated groups, showed overall regeneration of the hepatocyte of STZ-induced liver damage.
Conclusion: Lawsonia inermis Linn. leaf's ethyl acetate exerts its antihyperglycaemic and antioxidant activity and have hepatoprotective effects.
Keywords. Lawsonia inermis Linnaeus, ethyl acetate, antioxidant, hepatoprotective
