How high resolution x-ray crystal structures of D2-like dopamine receptors can guide the development of novel subtype-selective drugs

Bryan L. Roth

doi:10.1254/jpssuppl.WCP2018.0_SY20-4

WCP2018 (The 18th World Congress of Basic and Clinical Pharmacology)

Session ID : WCP2018_SY20-4

DOI https://doi.org/10.1254/jpssuppl.WCP2018.0_SY20-4

Conference information

Host: The Japanese Pharmacological Society, The Japanese Society of Clinical Pharmacology

Name : WCP2018 (18th World Congress of Basic and Clinical Pharmacology)

Location : Kyoto

Date : July 01, 2018 - July 06, 2018

Symposium

How high resolution x-ray crystal structures of D2-like dopamine receptors can guide the development of novel subtype-selective drugs

Bryan L. Roth

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Keywords: Dopamine receptors, GPCR

CONFERENCE PROCEEDINGS OPEN ACCESS

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Abstract

In this talk I will show how recent high resolution D2-family receptor structures have facilitated the design and validation of novel chemical probes for D2 and D4 dopamine receptors.

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