1997 Volume 57 Issue 2 Pages 74-78
Long-circulating thermosensitive liposomes with hyperosmotic internal aqueous phase intended for the delivery of macromolecules were prepared and characterized in vitro. Higher osmotic pressure markedly increased the release of macromolecules such as dextran. This effect was pronounced with liposome containing amphipathic polyethyleneglycol. The release of dextran was also influenced by the concentration of amphipathic polyethyleneglycol added to the liposomes. These results indicate that higher internal osmotic pressure and amphipathic polyethyleneglycol content contributes to the in vitro temperature-dependent release of the macromolecule dextran.
