1997 Volume 57 Issue 4 Pages 209-214
We examined the possibility of a pharmacokinetic interaction between theophylline (THP) and propentofylline (PRF) by administering them simultaneously via an intravenous (i.v.) route to rats. The area under the plasma concentration-time curve (AUC) value for THP after single bolus i.v. administration of aminophylline (2.5 mg/kg, THP equivalent) in combination with 6.25 or 12.5 mg/rat PRF, and the total body clearance (CLt) value for that with PRF (12.5 mg/rat) were significantly greater and smaller than those for the aminophylline-alone group, respectively. The mean residence time (MRT) value for THP tended to increase with the dose of PRF, while the volume of distribution at steady-state did not change. On the other hand, aminophylline (6.25 or 12.5 mg/rat) coadministered with PRF (2.5 mg/rat) significantly decreased the elimination rate constant for PRF and increased the MRT value, but 2.5 mg/rat aminophylline did not. The AUC value for PRF tended to increase with increasing doses of aminophylline, while the CLt value was inclined to decrease. In conclusion, it was found that there was a mutual pharmacokinetic interaction between THP and PRF in rats, however, the magnitude was relatively small.
