2000 Volume 60 Issue 4 Pages 253-260
To develop an ointment formulation suitable during the recovery stages of bedsores, including the proliferation period of granulation and the formative period of epidermis, the physicochemical properties of macrogol ointment (MO) containing various hydrophilic polymers, which have gel-forming ability, were tested. The resultant ointments were evaluated in drug-releasing property, hardness, and amount of water absorbed. Carbopol- (CP) added MO showed the highest water absorbing property, and the drug release from the base was also sustained (T50=65min). However, its hardness was too high to be clinically applied. When the mixture of CP and (hydroxypropyl cellulose) HPC was added to MO instead of CP, the hardness of the resultant ointment became a suitable value, and the sustained drug release property was also improved more (T50=90min) compared with the CP-added MO. The improved drug-releasing property was attributed to the improved water-absorbing rate of the ointment by the presence of HPC.
