Characterization of the Physicochemical Properties of Micelles Composed of a Novel Platelet Factor Receptor Antagonist, E5880

Abstract

E5880, a novel platelet factor receptor antagonist, was dispersed in a buffer solution (0.1 mg/ml, 10% lactose, pH 2.8) for use in an injectable formulation and the physicochemical properties of the resulting micelles were characterized. The critical micelle concentration of E5880 was 0.12 mM. Using area per molecule data, the critical packing parameter was calculated, and it was indicated that the structure is spherical and that the number of molecules per micelle is 46. The diameter of the micelle was 5.6 nm. The micropolarity around the hydrocarbon region of the micelle was similar to that of isobutanol.