Abstract
Fifty-four light breed mares suffering from difficulties of follicular development were treatedwith gonadotrophin given intramuscularly alone or in combination with intrauterine infusion. xperimental animals were allotted to four groups, each group being contained two subgroups ofanimals treated with gonadotrophin alone and animals received combined treatment. Since both group 3 and 4 contained a few animals and showed poor efficacy, the comparison of efficacy between simple onadotrophin treatment and combined treatment was done only for the group 1 and 2.
1. On the whole, the gonadotrophin treatment with or without uterine treatment yielded thefollowing results.
Mares injected with the combination of 5, 000 I. U. of PMS and 5, 000 I. U. of HCG (group 1), and 5, 000 I. U. of PMS and 2, 500 I. U. of HCG in oil suspension (group 2), were induced estrus in32 of 35 mares (91.4%) and 9 of 14 (64.3%) respectively. Mares treated with a single injection of 5, 000 I. U. of PMS (group 3) and 2, 500 I. U. of HCG in oil suspension (group 4) decame estrus in 1 of 2 (50%) and 1 of 3 (33.3%) respectively.
2. It is suggested that mares with difficulties of follicular development may be expected toshow normal estrus by a single intramuscular injection of 5, 000 I. U. of PMS and 5, 000 I. U. of HCG, or by additional injection of the same dose (or double doses) given 1014 days after theinitial administration when it is not effective.
3. In group 1 and 2, 21 of 24 mares (87.5%) with difficulties of follicular development in which ovaries were atrophic or corpus luteum-like structure persisted in ovaries, and did not show estroussigns, estrus occured by the PMS-HCG treatment and intrauterine infusion of gel-like substancethat was given into the uterus simultaneously or 10 to 14 days prior to gonadotrophin administr-ation.
In the similar cases in which non or poor development of follicle in normal sized ovary wasdetectable by rectal palpation and showed non or feeble estrus, 20 of 25 mares (80.0%) were inducedestrus with the gonadotrophin therapy.
