Effects of Prostaglandin F_2α, Prostaglandin E₂, Oxytocin and Platelet Activating Factor on Progesterone Output by Cultured Porcine Corpus Luteal Cells

Abstract

Prostaglandin (PG) E₂ at the final concentrations between 2010000 ng/ml, stimulated progesterone (P₄) output from the porcine corpus luteal cells in culture. It is suggested that PGE₂ has a luteotropic effect to porcine corpus lutea in vivo. PGF_2α did not have any clear effect on P₄ output from luteal cells. On the contrary, oxytocin and platelet activating factor have the suppressive effect on P₄ output from luteal cells in culture. These results mean that they have luteolytic effect to porcine corpus lutea.