The Journal of Reproduction and Development Supplement
The 102nd Meeting of the Society for Reproduction and Development
Session ID : P-101
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Epigenetic regulation of self-renewal related genes by DNA methylation in hematopoietic stem cell differentiation
*Yeoung-Gyu KoHwi-Cheul LeeSeongsoo HwangGi-Sun ImMi-Rung ParkByoung-Chul YangJae-Hyeon ChoJae-Seok WooSoo-Bong Park
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Abstract
Hematopoietic stem cells (HSCs) are cells with self-renewal and multilineage differentiation potential. Recent studies suggest that epigenetic modification plays an importance role in controlling stem cell differentiation and cell fate decisions. In this report, to determine whether DNA Methylation is involved in the regulation of factors related HSCs maintenance, we investigated the DNA methylation status of promoter locus of these factors and expression in prospectively purified mouse hematopoietic stem cell and progenitor cells. There was tissue-dependently differentially methylated region (T-DMR) in the 5’region of the genes related HSCs self-renewal. Here we propose that transcriptional regulation of Bmi1, Mel18 and P21 during HSC differentiation involves epigenetic system by DNA methylation.
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© 2009 Society for Reproduction and Development
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