2019 Volume 18 Pages 3-13
Background and Objective : GF13001 is an oral rehydration liquid containing 50 mEq/L sodium, 20 mEq/L potassium, 50 mEq/L chloride, and 100 mmol/L glucose. Rapid rehydration is one of the most important treatments for recovery of the fevered and dehydrated body in heatstroke. This study is aimed to evaluate whether the electrolytes and water in GF13001 are properly into the body, and whether this ameliorates the symptoms in heatstroke participants. Methods : Twenty five healthy subjects (male 17 ; female 8) received 3 continuous sessions of 10 min dry sauna bathing (58.8 - 67.9 degrees Celsius, WBGT INDEX) plus 5 min rest. After health check, they were divided at random into 1,000mL of GF13001 or mineral water ingested group. Some biomedical parameters (body weigth blood pressure, biomarkers in urine etc.) were compared between the two groups. Results : Heatstroke due to the sauna bathing revealed increase in body temperature and heart rate, and decrease in body weight and blood pressure. These changes recovered at 2 hours following intake of 1L of either electrolytes containing fluid similarly, with no significant difference. Urine volume was decreased and urine osmotic pressure and electrolyte (Na, K, Cl) concentration were increased due to the heatstroke. However, intake of GF13001 significantly suppressed increase in urine volume, decrease in osmotic pressure, and electrolyte concentration occurred at 2 hours following intake of the mineral water. Conclusions : Less excretion of urine volume and electrolyte was seen at 2 hours following GF13001 intake than the mineral water intake in the heatstroke participants. This result supports the idea that GF13001 constitutes the theoretical oral rehydration contents recommended by WHO. It is indicated that oral rehydration fluid GF13001 may be appropriate for prevention of and recovery in dehydration due to the heatstroke, hard training, excessive exercise, and so on.
https://ror.org/03kw7j946 