Current Topics in DNA Double-Strand Break Repair

Junya KOBAYASHI; Kuniyoshi IWABUCHI; Kiyoshi MIYAGAWA; Eiichiro SONODA; Keiji SUZUKI; Minoru TAKATA; Hiroshi TAUCHI

doi:10.1269/jrr.07130

Review

Current Topics in DNA Double-Strand Break Repair

Junya KOBAYASHI, Kuniyoshi IWABUCHI, Kiyoshi MIYAGAWA, Eiichiro SONODA, Keiji SUZUKI, Minoru TAKATA, Hiroshi TAUCHI

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Keywords: DNA repair, Homologous recombination, Nuclear foci, Non-homologous end joining

JOURNAL FREE ACCESS

2008 Volume 49 Issue 2 Pages 93-103

DOI https://doi.org/10.1269/jrr.07130

View "Advance Publication" version (February 19, 2008).

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Abstract

DNA double strand break (DSB) is one of the most critical types of damage which is induced by ionizing radiation. In this review, we summarize current progress in investigations on the function of DSB repair-related proteins. We focused on recent findings in the analysis of the function of proteins such as 53BP1, histone H2AX, Mus81-Eme1, Fanc complex, and UBC13, which are found to be related to homologous recombination repair or to non-homologous end joining. In addition to the function of these proteins in DSB repair, the biological function of nuclear foci formation following DSB induction is discussed.

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