Journal of Radiation Research
Online ISSN : 1349-9157
Print ISSN : 0449-3060
Regular Papers
Analysis of Gene Expression in a Human-derived Glial Cell Line Exposed to 2.45 GHz Continuous Radiofrequency Electromagnetic Fields
Tomonori SAKURAITomoko KIYOKAWAEijiro NARITAYukihisa SUZUKIMasao TAKIJunji MIYAKOSHI
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JOURNAL FREE ACCESS

2011 Volume 52 Issue 2 Pages 185-192

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Abstract
The increasing use of mobile phones has aroused public concern regarding the potential health risks of radiofrequency (RF) fields. We investigated the effects of exposure to RF fields (2.45 GHz, continuous wave) at specific absorption rate (SAR) of 1, 5, and 10 W/kg for 1, 4, and 24 h on gene expression in a normal human glial cell line, SVGp12, using DNA microarray. Microarray analysis revealed 23 assigned gene spots and 5 non-assigned gene spots as prospective altered gene spots. Twenty-two genes out of the 23 assigned gene spots were further analyzed by reverse transcription-polymerase chain reaction to validate the results of microarray, and no significant alterations in gene expression were observed. Under the experimental conditions used in this study, we found no evidence that exposure to RF fields affected gene expression in SVGp12 cells.
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© 2011 by Journal of Radiation Research Editorial Committee
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