Journal of Radiation Research
Online ISSN : 1349-9157
Print ISSN : 0449-3060
Extremely Low Frequency Magnetic Fields Do Not Elicit Oxidative Stress in MCF10A Cells
Mi-Na HONGNa-Kyung HANHyung-Chul LEEYoung-Kyu KOSung-Gil CHIYun-Sil LEEYoon-Myung GIMMSung-Ho MYUNGJae-Seon LEE
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2012 Volume 53 Issue 1 Pages 79-86


The aim of this study was to determine whether extremely low frequency magnetic fields (ELF-MF) could affect intracellular reactive oxygen species (ROS) levels and antioxidant enzyme activity. After MCF10A human breast epithelial cells were exposed to 1 mT of 60 Hz ELF-MF for 4 hours, intracellular ROS level, superoxide dismutase (SOD) activity, and reduced to oxidized glutathione (GSH/GSSG) ratio were measured. The cells exposed to ELF-MF did not evidence statistically significant changes in the above-mentioned biological parameters as compared to either the incubator controls or sham-exposed cells. By way of contrast, the IR-exposed cells exhibited marked changes in ROS level, SOD activity, and GSH/GSSG ratio. When we assessed morphological changes and senescence-associated beta-galactosidase (SA-β-Gal) activity, only the IR-exposed cells were positive. According to our results, it could be concluded that ELF-MF has no effect on intracellular ROS level, SOD activity, and GSH/GSSG ratio under our exposure condition.

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© 2012 by Journal of Radiation Research Editorial Committee
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