Effect of Protein Synthesis Inhibitor on Accumulation of Fructose-1, 6-diphosphate in Irradiated Rat Thymocytes

Abstract

It has been already shown that ionizing radiation brings about the enhancement of phosphofructokinase reaction in rat thymocytes and a consequent accumulation of fructose-1, 6-diphosphate. Protein synthesis inhibitor, such as cycloheximide was shown to have no effect on this accumulation. Explanation of fructose-1, 6-diphosphate accumulation in terms of the stimulated de novo synthesis of phosphofructokinase could be, therefore, ruled out.