Radioprotective Potency of Thiazine and Thiazole Derivatives

Abstract

2-Amino-4, 6, 6-trimethyl-1, 3-thiazine and 2-amino-4-methylthiazole demonstrated a radioprotective action in mice irradiated with 70O R of X-rays, but did not show any protective action on radiation-induced killing of cultured HeLa cells. Since no evidence of liberation of SH group through ring opening was observed, the protective action of the compound in mice might be due to its pharmacological action.