Radiation Carcinogenesis in Mouse Skin and Its Threshold-like Response

HIROSHI TANOOKA; AKIRA OOTSUYAMA

doi:10.1269/jrr.32.SUPPLEMENT2_195

Journal of Radiation Research

Online ISSN : 1349-9157
Print ISSN : 0449-3060

Radiation Carcinogenesis in Mouse Skin and Its Threshold-like Response

HIROSHI TANOOKA, AKIRA OOTSUYAMA

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Keywords: Mouse skin, Repeated beta radiation, Tumor, Threshold dose

JOURNAL FREE ACCESS

1991 Volume 32 Issue SUPPLEMENT2 Pages 195-201

DOI https://doi.org/10.1269/jrr.32.SUPPLEMENT2_195

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Abstract

Experiments on the dose-response of tumor development induced by repeated local beta irradiation of the back of mice are summarized. Results indicated a 100% tumor incidence on irradiation at 2.5-11.8 Gy per exposure (dose-saturation effect) and the threshold-like dose response at lower doses. The mechanism underlying these phenomena is discussed on the basis of the tissue-misrepair model, that is misrepair caused by repeated stimulation of cell growth after repeated tissue injury.

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