Journal of Radiation Research
Online ISSN : 1349-9157
Print ISSN : 0449-3060
Rapid Decrease in Brain Enkephalin Content after Low-dose Whole-body X-Irradiation of the Rat
YUKIHISA MIYACHINORIO OGAWAAKITANE MORI
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1992 Volume 33 Issue 1 Pages 11-15

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Abstract

Methionine-enkephalin (ME) contents in the hypothalamus and other rat brain structures were measured immediately after 10 or 20 cGy whole-body X-irradiation. The ME contents of homogenates of the striatum, hypothalamus, midbrain + thalamus, hindbrain and pituitary were assayed radioimmunologically with 125I. The contents of all the structures, except the pituitary, decreased significantly after 20 cGy irradiation. The reduction in the hypothalamus was transient, ME content gradually recovering with time. These results suggest that the central nervous system of mammals is one of the most radiosensitive organs as judged by changes in stress-induced mediators such as ME.

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