Protection Mechanisms of Non-malignant and Malignant Cells against Ionizing Radiation I. The Cytological Effects of 2-mercaptoethylamine on the Rat and Mouse Ascites Tumors
1964 Volume 5 Issue 3-4 Pages 166-171
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1964 Volume 5 Issue 3-4 Pages 166-171
The present study deals with cytological effects of 2-mercaptoethylamine on the Yoshida-sarcoma, the MTK-sarcoma III and Ehrlich ascites tumor concentrating a special attention on cell growth of tumor.
2-Mercaptoethylamine exerts influence upon tumor cells in process of mitosis, especially on an increase of mitotic cells, leading to increase of prophasic cells at first and metaphasic cells secondarily.
The protection mechanism against radiation exerted by 2-mercaptoethylamine indicated that this drug induced an increase of mitotic activity. This increase of mitotic activity might be interpreted as a protecting effect against radiation injury.
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