Abstract
Intestinal mucosal epithelial cells and lymphocytes were both severely injuried by radiation, which leaded to endogenous infection and intestinal dysfunction. The ralated mechanisms were approved that proliferating activity and cytotoxicity of intraepithelial lymphocytes decreased, meanwhile TNF-α and TGF-β genes expression increased, the quantity of plasma cells secreted IgA and IL-4 gene expression were depressed. On the other hand, necrosis or apoptosis of intestinal crypt cells, structure abnormality and deletion of villi leaded to intestinal dysfunction. Analyzed the gene profiles and protein expression of irradiated intestinal epithelium and observed that R1S1, a new gene, and R1S2 genes specially expressed after 3h, but R2S2 and R2S5 genes expressed after 96h. PrxI and ERP29 proteins induced by radiation high expressed and identified PrxI had a radioprotective function. 20kD protein isolated from burned serum, glucagons-like peptide-2, rhIL-4 and human defensin5 were effective to promote the recovery of intestinal mucosal immune and epithelia so decreasing the incidence of endogenous infection and restoring intestine function. [J Radiat Res 44:370 (2003)]
